CD137
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| Recettore del fattore di necrosi tissutale 9 | |
|---|---|
| Gene | |
| HUGO | TNFRSF14 4-1BB; CD137; CDw137; ILA |
| Entrez | 3604 |
| Locus | Chr. 1 p36.23 |
| Proteina | |
| OMIM | 602250 |
| UniProt | Q07011 |
CD137, noto anche come recettore del fattore di necrosi tumorale 9, 4-1BB e ILA (dall'acronimo in lingua inglese induced by lymphocyte activation) è una proteina recettoriale che, nell'essere umano, è codificata dal gene TNFRSF9 e fa parte della superfamiglia dei recettori del fattore di necrosi tumorale.
Espressione e funzione
Si trova espresso nei linfociti T attivati, in particolar modo quelli citotossici (CD8+), nelle cellule dendritiche, nelle cellule NK, nei granulociti e nelle cellule endoteliali situate in siti di infiammazione. Agisce incentivando la proliferazione e la sopravvivenza dei linfociti T, l'attività citolitica e la produzione di interleuchina 2; inoltre, nei topi, ha dimostrato un'attività di potenziamento della risposta immunitaria contro le cellule tumorali. Agisce legando TRAF2.
Approfondimenti
- Schwarz H, Biological activities of reverse signal transduction through CD137 ligand, in J. Leukoc. Biol., vol. 77, n. 3, 2005, pp. 281–6, DOI:10.1189/jlb.0904558, PMID 15618293.
- Kwon BS, Weissman SM, cDNA sequences of two inducible T-cell genes, in Proc. Natl. Acad. Sci. U.S.A., vol. 86, n. 6, 1989, pp. 1963–7, DOI:10.1073/pnas.86.6.1963, PMC 286825, PMID 2784565.
- Zhou Z, Kim S, Hurtado J, ZH Lee, KK Kim, KE Pollok e BS Kwon, Characterization of human homologue of 4-1BB and its ligand, in Immunol. Lett., vol. 45, 1–2, 1995, pp. 67–73, DOI:10.1016/0165-2478(94)00227-I, PMID 7622190.
- Alderson MR, Smith CA, Tough TW, Terri Davis-Smith, Richard J. Armitage, Ben Falk, Eileen Roux, Elizabeth Baker e Grant R. Sutherland, Molecular and biological characterization of human 4-1BB and its ligand, in Eur. J. Immunol., vol. 24, n. 9, 1994, pp. 2219–27, DOI:10.1002/eji.1830240943, PMID 8088337.
- Schwarz H, Tuckwell J, Lotz M, A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family, in Gene, vol. 134, n. 2, 1994, pp. 295–8, DOI:10.1016/0378-1119(93)90110-O, PMID 8262389.
- Loo DT, Chalupny NJ, Bajorath J, WW Shuford, RS Mittler e A Aruffo, Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB, in J. Biol. Chem., vol. 272, n. 10, 1997, pp. 6448–56, DOI:10.1074/jbc.272.10.6448, PMID 9045669.
- Schwarz H, Arden K, Lotz M, CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies, in Biochem. Biophys. Res. Commun., vol. 235, n. 3, 1997, pp. 699–703, DOI:10.1006/bbrc.1997.6870, PMID 9207223.
- Arch RH, Thompson CB, 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB, in Mol. Cell. Biol., vol. 18, n. 1, 1998, pp. 558–65, PMC 121523, PMID 9418902.
- Jang IK, Lee ZH, Kim YJ, Seung H. Kim e Byoung S. Kwon, Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B, in Biochem. Biophys. Res. Commun., vol. 242, n. 3, 1998, pp. 613–20, DOI:10.1006/bbrc.1997.8016, PMID 9464265.
- Kim YJ, Kim SH, Mantel P, Kwon BS, <881::AID-IMMU881>3.0.CO;2-0 Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses, in Eur. J. Immunol., vol. 28, n. 3, 1998, pp. 881–90, DOI:10.1002/(SICI)1521-4141(199803)28:03<881::AID-IMMU881>3.0.CO;2-0, PMID 9541583.
- Saoulli K, Lee SY, Cannons JL, WC Yeh, A Santana, MD Goldstein, N Bangia, MA Debenedette e TW Mak, CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand, in J. Exp. Med., vol. 187, n. 11, 1998, pp. 1849–62, DOI:10.1084/jem.187.11.1849, PMC 2212301, PMID 9607925.
- Langstein J, Michel J, Schwarz H, CD137 induces proliferation and endomitosis in monocytes, in Blood, vol. 94, n. 9, 1999, pp. 3161–8, PMID 10556203.
- Jang LK, Lee ZH, Kim HH, JM Hill, JD Kim e BS Kwon, A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction, in Mol. Cells, vol. 12, n. 3, 2002, pp. 304–12, PMID 11804328.
- Cooper D, Bansal-Pakala P, Croft M, <521::AID-IMMU521>3.0.CO;2-X 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity, in Eur. J. Immunol., vol. 32, n. 2, 2002, pp. 521–9, DOI:10.1002/1521-4141(200202)32:2<521::AID-IMMU521>3.0.CO;2-X, PMID 11828369.
- Wilcox RA, Chapoval AI, Gorski KS, M Otsuji, T Shin, DB Flies, K Tamada, RS Mittler e H Tsuchiya, Cutting edge: Expression of functional CD137 receptor by dendritic cells, in J. Immunol., vol. 168, n. 9, 2002, pp. 4262–7, PMID 11970964.
- Shulzhenko N, Morgun A, Chinellato AP, GF Rampim, RV Diniz, DR Almeida e M Gerbase-Delima, CD27 but not CD70 and 4-1BB intragraft gene expression is a risk factor for acute cardiac allograft rejection in humans, in Transplant. Proc., vol. 34, n. 2, 2002, pp. 474–5, DOI:10.1016/S0041-1345(02)02600-3, PMID 12009595.
- Pauly S, Broll K, Wittmann M, G Giegerich e H Schwarz, CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers, in J. Leukoc. Biol., vol. 72, n. 1, 2002, pp. 35–42, PMID 12101260.